细胞因子
Catalog Number: KD-018
Pr…
Species
Human
Protein Construction
FGF-4 (Ser54-Leu206), Accession # P08620
Tag
No tag |
Expression System
E. coli
Purity
> 95% as determined by SDS-PAGE
Predicted Molecular Mass
17 kDa SDS-PAGE17 kDa, under reducing conditions |
Endotoxin
<0.1 EU/μg of the protein by the LAL method.
Biological Activity
Measured in a cell proliferation assay using NIH/ 3T3 cells. The ED50 for this effect is 10-55 ng/mL.
Formulation
Lyophilized from a 0.22μm filtered solution in PBS (500mM NaCl) with 0.1%BSA
Reconstitution
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water
Storage&Stability
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, at lower than -70 °C as supplied.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
1 month, -20 to -70 °C under sterile conditions after reconstitution.
Usage
Research use only |
Background
Fibroblast Growth Factor-4 (FGF-4), FGFK or KFGF (Kaposi’s sarcoma associated FGF), is a heparin-binding growth factor of the FGF family. It was identified by its oncogenic transforming activity. FGF-4 and FGF-3 are located closely on chromosome 11. FGF-4 and its receptors (FGF R1c, 2c, 3c and 4) play an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. FGF-4 is required for normal limb and cardiac valve development during embryogenesis. FGF4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.
KD-018-datasheet- FGF-4.ver2.pdf
Data
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