细胞因子
Catalog Number: KD-020
Pr…
Species
Human
Protein Construction
FGF-16 (Ala2-Arg207), Accession # O43320
Tag
No tag |
Expression System
E. coli
Purity
> 95% as determined by SDS-PAGE
Predicted Molecular Mass
24 kDa SDS-PAGE23 kDa, under reducing conditions |
Endotoxin
<0.01 EU/μg of the protein by the LAL method.
Biological Activity
Measured in a cell proliferation assay using Balb/ 3T3 cells. The ED50 for this effect is <30 ng/mL.
Formulation
Lyophilized from a 0.22μm filtered solution in PBS with EDTA
Reconstitution
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water
Storage&Stability
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, at lower than -70 °C as supplied.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
1 month, -20 to -70 °C under sterile conditions after reconstitution.
Usage
Research use only |
Background
Fibroblast Growth Factor-16 (FGF-16) is a heparin binding growth factor, a member of the FGF family. All FGF family members are heparin binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue. FGF-16 is most similar to FGF-9 (73 % amino acid identity). The protein sequence of human FGF-16 displays 98.6% identity with rat FGF-16. Chimpanzee FGF-16 (207 amino acids), chicken FGF-16 (207 amino acids), and zebrafish FGF-16 (203 amino acids) show 100 %, 89.9 %, and 79.2 % total amino acid identity with human FGF-16.
Data
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